雷雷，博士.D.
教授
位置
教授 Lei has worked at the University of New England since July, 2010. He teaches undergraduate courses such as Cell and Molecular Biology (BIO 370), 发育生物学(bio407), 和发育神经生物学(BIO 450). He treasures undergraduate education and was given the Debra J. Summers Memorial Award for Teaching Excellence in 2018.
除了课堂教学, 教授 Lei conducts research on two seemingly distinct but intimately connected topics: 1) transcriptional regulation of gene expression in neural development and 2) origin of life and the evolution of the genetic code. He has published in high profile journals on both topics, often involving contributions from student researchers that he mentored.
凭证
教育
博士后训练
研究
目前的研究
Sox11在慢性疼痛中的作用
Sox11在皮质发育中的功能
role of Klf7 in cortical development and neurological disorders
选定的出版物
雷,我. 伯顿，Z。.F. (2022) “Superwobbling” and tRNA-34 wobble and tRNA-37 anticodon loop modifications in evolution and devolution of the genetic code. 生命12:252.
雷,我. 伯顿，Z。.F. (2021)遗传密码的进化. 转录12,28 -53.
雷,我. 伯顿，Z。.F. (2021) Early evolution of transcription systems and divergence of Archaea and Bacteria. 分子生物科学前沿.
雷,我. 伯顿，Z。.F. (2020) Evolution of life on Earth: tRNA, aminoacyl-tRNA synthetases and the genetic code. 生活10:21.
Welsbie D.S.米切尔，K.L.兰甘纳坦，V.， Sluch, V.M.，杨，Z.Kim, J.比勒，E.帕特尔，A.马丁，S.张，P.W.， Ge, Y.， Duan, Y.富勒.金，B.J.哈默德，E.， Chamling, X.雷，L.弗雷泽，我.D.C.罗奈，Z.A.柏林尼克，C.A.扎克，D.J. (2017) Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons. 神经科学杂志(94):1142-1154.
缅甸人,米.A.西蒙斯，C.A.休斯，M。.雷，L. (2014) Developing and validating trace fear conditioning protocols in C57BL/6 mice. 神经科学学报，222,111-7.
王,Y.林，L.，黎，H.帕拉达，L.F.雷，L.* (2013). Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. 发展动力学242,638-53. *通讯作者.
林,我.李，V.王，Y.林，J.， Sock, E.韦格纳，M.雷，L.* (2011). Sox11 regulates survival and axonal growth of embryonic sensory neurons. 《全球网络赌博平台》(英文版)，52-64. *通讯作者.
罗梅罗,M.林，L.Lush, M.雷，L.帕拉达，L.F.，朱，Y. (2007). Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. 中国生物医学工程学报(英文版)，27 (2):444 - 444.
雷,我.*和帕拉达，L.F. (2007). Transcriptional regulation of Trk family neurotrophin receptors (Invited review). 细胞与分子生命科学64,522-532. *通讯作者.
雷,我.周杰.林，L.L .帕拉达(Parada).F. (2006). Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons. 生物工程学报，2003,18 (2):558 - 569.
雷,我.， 到来,F.Lush, M.罗梅罗，M.周杰.Luikart, B.克莱斯，L.拉米雷斯，F.L .帕拉达(Parada).F. (2005). The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons. 基因 & 发展19,1354-1364.
到来,F.雷，L.住吉，H.鹿村，D.德拉戈米尔，C.斯莫尔顿，S.普切，A.C.彼得斯，T.J.梅森，C.帕拉达，L.F.拉米雷斯，F. (2005). Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nerv¬ous system. 中国生物医学工程学报，25 (2):591 - 591.
妈,我.雷，L.，工学学士.R.特纳，E.L .帕拉达(Parada).F. (2003). Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. 130,3525 -3534.
雷,我.，妈，L.，内华达州，南卡罗来纳州.泰语，T.L .帕拉达(Parada).F. (2001). mKlf7, a potential transcriptional regulator of trkA nerve growth factor receptor expression in sensory and sympathetic neurons. 发展128,1147-1158.
雷,我.，任，D.伯顿，Z.F. (1999). The RAP74 subunit of human transcription factor IIF has similar roles in initiation and 伸长. 中国生物医学工程学报(英文版)，19 (3):372- 382.
任,D.雷，L.伯顿，Z.F. (1999). A region within the RAP74 subunit of human transcription factor IIF is critical for initiation but dispensable for complex assembly. 分子与细胞生物学19,3777 -7387.
雷,我.，任，D.芬克尔斯坦，A.伯顿，Z.F. (1998). Functions of the N- and C-terminal domains of human RAP74 in initiation, 伸长, RNA聚合酶II的再循环. 中国生物医学工程学报，18 (2):481 - 481.
王,B.Q.雷，L.伯顿，Z.F. (1994). Importance of codon preference for production of human RAP74 and reconstitution of the RAP30/74 complex. 蛋白表达与纯化，5,476-485.
其他学术活动
邀请研讨会
The 31st Annual Meeting of the Society for Neuroscience. November 10-15, 2001; San Diego, California.
1st Annual Neuroscience Symposium cosponsored by the Barrow Neurological Institute and 亚利桑那州 State University.
University of Southern 缅因州, Portland, 缅因州, December 6, 2012.
第38届缅因州生物和医学科学研讨会, MDIBL, 索尔兹伯里湾, 缅因州, 4月15 - 16, 2011.
缅因州 Medical Center 研究 Institute, Scarborough, 缅因州, February 17, 2011.
资助基金
NIH R01: Role of the nerve regeneration-associated gene Sox11 in promoting corneal innervation and reducing epithelial cell damage in dry eye. PI: Ian Meng，全球网络赌博平台.
P20GM103643, NIH /美国, COBRE: Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function. PD: Ian Meng，全球网络赌博平台.
Society for 发育生物学 Teaching Faculty Travel Grant. 皮:雷雷，全球网络赌博平台.
亚利桑那州生物医学研究委员会. 皮:雷雷，亚利桑那州立大学.
ASU and Mayo Clinic 亚利桑那州 Partnership for Collaborative 研究 Seed Grant Program. 皮:雷雷，亚利桑那州立大学.
露丝L. Kirschstein National 研究 Service Award Postdoctoral Fellowship (F32), NINDS, NIH. 皮:雷磊，德克萨斯大学西南医学中心.
邀请全体发言
The Northeast Regional IDeA Conference, Bar Harbor, 缅因州, September 24-26, 2015.
The Gordon 研究 Conference on Neurotrophic Factors, June 2-7, 2013; Newport, RI.
Quebec Pain 研究 Network Annual Meeting, Saint-Sauveur, Quebec, Canada, January 25-27, 2013.
Department of Biology, University of Southern 缅因州, Portland, 缅因州, December 6, 2012.
第38届缅因州生物和医学科学研讨会, MDIBL, 索尔兹伯里湾, 缅因州, 4月15 - 16, 2011.
缅因州 Medical Center 研究 Institute, Scarborough, 缅因州, February 17, 2011.
Cell Biology Department, Medical College of Wisconsin, Milwaukee, Wisconsin, February 19, 2009.
Barrow Neurological Institute, 凤凰城, 亚利桑那州, February 5, 2009.
先进红外线技术及应用2007. 利昂，墨西哥，2007年10月8-12日.
First Annual Neuroscience Symposium cosponsored by the Barrow Neurological Institute and 亚利桑那州 State University, 凤凰城, 亚利桑那州, 11月4日, 2006.
The 31st Annual Meeting of the Society for Neuroscience. November 10-15, 2001; San Diego, California.
研究兴趣
生命的起源和遗传密码的进化
Transcriptional regulation of gene expression in development and diseases